Distinct regulatory roles of transforming growth factor-β and interleukin-4 in the development and maintenance of natural and induced CD4(+) CD25(+) Foxp3(+) regulatory T cells

The development and function of CD4(+) CD25(+) Foxp3(+) regulatory T cells (Tregs) are strictly regulated by cytokines. Here we show that transforming growth factor-β (TGF-β) and interleukin-4 (IL-4) play a crucial and antagonistic role in the development of Tregs. Additionally, these cytokines also...

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Detalhes bibliográficos
Main Authors: Prochazkova, Jana, Fric, Jan, Pokorna, Katerina, Neuwirth, Ales, Krulova, Magdalena, Zajicova, Alena, Holan, Vladimir
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2009
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2753931/
https://ncbi.nlm.nih.gov/pubmed/19740328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2009.03060.x
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