Loss of inhibin alpha uncouples oocyte-granulosa dynamics and disrupts postnatal folliculogenesis

Targeted disruption of the inhibin α gene (Inha(−/−)) in mice results in an ovarian phenotype of granulosa cell tumors that renders the animals infertile. Little is known about the reproductive defects prior to tumor development. Here, we report novel data on early follicle dynamics in Inha(−/−) mic...

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Main Authors: Myers, Michelle, Middlebrook, Brooke S., Matzuk, Martin M., Pangas, Stephanie A.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2753717/
https://ncbi.nlm.nih.gov/pubmed/19666016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2009.08.001
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