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Highly sensitive and selective oligonucleotide sensor for sickle cell disease gene using photon upconverting nanoparticles

We report the design of an oligonucleotide sensor for the detection of point mutation associated with sickle cell disease. The sensor was based on luminescence resonance energy transfer between a donor and an acceptor. Photon upconverting nanoparticles (NaYF(4) doped with Yb(3+) and Er(3+)) were use...

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Autores principales: Kumar, Manoj, Guo, Yanyan, Zhang, Peng
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2753611/
https://ncbi.nlm.nih.gov/pubmed/18823772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bios.2008.08.023
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