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Advanced Glycation End-products Accumulate in Vascular Smooth Muscle and Modify Vascular but not Ventricular Properties in Elderly Hypertensive Canines
BACKGROUND: Advanced glycation end-products (AGEs) are believed to increase ventricular (LV) and vascular stiffness, in part via cross-linking proteins. We determined if and where AGEs were increased in elderly hypertensive non-diabetic dogs and whether an AGE cross-link breaker (ALT-711) improved v...
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Main Authors: | , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2008
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2753480/ https://ncbi.nlm.nih.gov/pubmed/18711013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.108.777326 |
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