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Advanced Glycation End-products Accumulate in Vascular Smooth Muscle and Modify Vascular but not Ventricular Properties in Elderly Hypertensive Canines

BACKGROUND: Advanced glycation end-products (AGEs) are believed to increase ventricular (LV) and vascular stiffness, in part via cross-linking proteins. We determined if and where AGEs were increased in elderly hypertensive non-diabetic dogs and whether an AGE cross-link breaker (ALT-711) improved v...

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Detalhes bibliográficos
Main Authors: Shapiro, Brian P., Owan, Theophilus E., Mohammed, Selma F., Meyer, Donna M., Mills, Lisa D., Schalkwijk, Casper G., Redfield, Margaret M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2753480/
https://ncbi.nlm.nih.gov/pubmed/18711013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.108.777326
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