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GuaA and GuaB Are Essential for Borrelia burgdorferi Survival in the Tick-Mouse Infection Cycle

Pathogens lacking the enzymatic pathways for de novo purine biosynthesis are required to salvage purines and pyrimidines from the host environment for synthesis of DNA and RNA. Two key enzymes in purine salvage pathways are IMP dehydrogenase (GuaB) and GMP synthase (GuaA), encoded by the guaB and gu...

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Bibliografske podrobnosti
Main Authors: Jewett, Mollie W., Lawrence, Kevin A., Bestor, Aaron, Byram, Rebecca, Gherardini, Frank, Rosa, Patricia A.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2753021/
https://ncbi.nlm.nih.gov/pubmed/19666713
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00450-09
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