Crystal structure of the catalytic domain of the tumor-associated human carbonic anhydrase IX

Carbonic anhydrase (CA) IX is a plasma membrane-associated member of the α-CA enzyme family, which is involved in solid tumor acidification. It is a marker of tumor hypoxia and a prognostic factor in several human cancers. An aberrant increase in CA IX expression in chronic hypoxia and during develo...

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Main Authors: Alterio, Vincenzo, Hilvo, Mika, Di Fiore, Anna, Supuran, Claudiu T., Pan, Peiwen, Parkkila, Seppo, Scaloni, Andrea, Pastorek, Jaromir, Pastorekova, Silvia, Pedone, Carlo, Scozzafava, Andrea, Monti, Simona Maria, De Simone, Giuseppina
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752527/
https://ncbi.nlm.nih.gov/pubmed/19805286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908301106
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