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Model-based development of gemcabene, a new lipid-altering agent

The purpose of this study was to evaluate the value of model-based, quantitative decision making during the development of gemcabene, a novel lipid-altering agent. The decisions were driven by a model of the likely clinical profile of gemcabene in comparison with its competitors, such as 3-hydroxyme...

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Main Authors: Mandema, Jaap W., Hermann, David, Wang, Wenping, Sheiner, Tim, Milad, Mark, Bakker-Arkema, Rebecca, Hartman, Daniel
Format: Artigo
Jezik:Inglês
Izdano: Springer-Verlag 2005
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2751254/
https://ncbi.nlm.nih.gov/pubmed/16353929
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/aapsj070352
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