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Electronic and resonance effects on the lonization of structural analogues of efavirenz
The solubility of 4 analogues of efavirenz was studied as a function of pH. The study evaluated the ionization behavior and determined the relative contribution of electronegative substituents versus resonance effects on the pK(a) value of the cyclic carbamate. The most profound lowering effect on t...
में बचाया:
| मुख्य लेखकों: | , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Springer-Verlag
2001
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2751217/ https://ncbi.nlm.nih.gov/pubmed/12049491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/ps030428 |
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