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Independence of substituent contributions to the transport of small-molecule permeants in lipid bilayer

Purpose: To explore the independence of functional group contributions to permeability of nonelectrolytes across egg lecithin bilayers. Methods. The transport rates were measured of a series of α-substituted p-methylhippuric acids (-H,-Cl,-OCH(3),-CN,-OH,-COOH, and-CONH(2)) across egg lecithin lipid...

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Detalhes bibliográficos
Main Authors: Mayer, Peter T., Xiang, Tian-Xiang, Anderson, Bradley D.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2000
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2751028/
https://ncbi.nlm.nih.gov/pubmed/11741230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/ps020214
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