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Independence of substituent contributions to the transport of small-molecule permeants in lipid bilayer
Purpose: To explore the independence of functional group contributions to permeability of nonelectrolytes across egg lecithin bilayers. Methods. The transport rates were measured of a series of α-substituted p-methylhippuric acids (-H,-Cl,-OCH(3),-CN,-OH,-COOH, and-CONH(2)) across egg lecithin lipid...
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Main Authors: | , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Springer-Verlag
2000
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2751028/ https://ncbi.nlm.nih.gov/pubmed/11741230 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/ps020214 |
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