Matrix metalloproteinase-10 is a critical effector of protein kinase Cι-Par6α-mediated lung cancer

Protein kinase Cι (PKCι) drives transformed growth of non-small cell lung cancer (NSCLC) cells through the Rho family GTPase Rac1. We show here that PKCι activates Rac1 in NSCLC cells by formation of a PKCι–Par6α complex that drives anchorage-independent growth and invasion through activation of mat...

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Bibliographic Details
Main Authors: Frederick, LA, Matthews, JA, Jamieson, L, Justilien, V, Thompson, EA, Radisky, DC, Fields, AP
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2750877/
https://ncbi.nlm.nih.gov/pubmed/18427549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2008.119
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