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Effects of water vapor absorption on the physical and chemical stability of amorphous sodium indomethacin

This study reports on the effects that water absorbed into amorphous sodium indomethacin (NaIMC) can have on simultaneous tendencies to crystallize to its trihydrate form and to undergo base-catalyzed hydrolysis because of the plasticizing effects of water on molecular mobility. Measurement of water...

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Detalhes bibliográficos
Main Authors: Tong, Ping, Zografi, George
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2750461/
https://ncbi.nlm.nih.gov/pubmed/15760084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/pt050226
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