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The influence of swelling capacity of superdisintegrants in different pH media on the dissolution of hydrochlorothiazide from directly compressed tablets

The purpose of this study was to investigate the efficiency of superdisintegrants in promoting tablet disintegration and drug dissolution under varied media pH. Significant reductions in the rate and extent of water uptake and swelling were observed for both sodium starch glycolate (Primojel) and cr...

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Bibliografiske detaljer
Main Authors: Zhao, Na, Augsburger, Larry L.
Format: Artigo
Sprog:Inglês
Udgivet: Springer-Verlag 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2750420/
https://ncbi.nlm.nih.gov/pubmed/16353956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/pt060119
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