DHEA-dependent and organ-specific regulation of TNF-α mRNA expression in a murine polymicrobial sepsis and trauma model

INTRODUCTION: Dehydroepiandrosterone (DHEA) improves survival after trauma and sepsis, while mechanisms of action are not yet fully understood. Therefore, we investigated the influence of DHEA on local cytokine expression in a two-hit model. METHODS: Male NMRI mice were subjected to femur fracture/h...

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Detalhes bibliográficos
Main Authors: Barkhausen, Tanja, Hildebrand, Frank, Krettek, Christian, van Griensven, Martijn
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2750161/
https://ncbi.nlm.nih.gov/pubmed/19594900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/cc7963
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