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(1R, 3S)-(−)-Trans-PAT: A novel full-efficacy serotonin 5-HT(2C) receptor agonist with 5-HT(2A) and 5-HT(2B) receptor inverse agonist/antagonist activity
The serotonin 5-HT(2A), 5-HT(2B), and 5-HT(2C) G protein-coupled receptors signal primarily through Gα(q) to activate phospholipase C (PLC) and formation of inositol phosphates (IP) and diacylglycerol. The human 5-HT(2C) receptor, expressed exclusively in the central nervous system, is involved in s...
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| Autores principales: | , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2009
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2749987/ https://ncbi.nlm.nih.gov/pubmed/19397907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejphar.2009.04.035 |
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