Protective effect of geranylgeranylacetone, an inducer of heat shock protein 70, against drug-induced lung injury/fibrosis in an animal model

BACKGROUND: To determine whether oral administration of geranylgeranylacetone (GGA), a nontoxic anti-ulcer drug that is an inducer of heat shock protein (HSP) 70, protects against drug-induced lung injury/fibrosis in vivo. METHODS: We used a bleomycin (BLM)-induced lung fibrosis model in which mice...

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Detalhes bibliográficos
Main Authors: Fujibayashi, Takayoshi, Hashimoto, Naozumi, Jijiwa, Mayumi, Hasegawa, Yoshinori, Kojima, Toshihisa, Ishiguro, Naoki
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749802/
https://ncbi.nlm.nih.gov/pubmed/19758434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2466-9-45
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