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Highly parallel measurements of interaction kinetic constants with a microfabricated optomechanical device

We used mechanical trapping of molecular interactions to demonstrate a highly parallel approach to measure the kinetics of biomolecular interactions. This approach consumes 25 fmol of material per measurement and permits 320 measurements in a single experiment. We measured association and dissociati...

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Bibliographic Details
Main Authors: Bates, Steven R., Quake, Stephen R.
Format: Artigo
Language:Inglês
Published: American Institute of Physics 2009
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749446/
https://ncbi.nlm.nih.gov/pubmed/19777091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1063/1.3211382
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