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Evaluating the antipsychotic profile of the preferential PDE10A inhibitor, papaverine
RATIONALE: Prepulse inhibition (PPI) is an operational measure of sensorimotor gating that is deficient in schizophrenia patients. In rats, PPI deficits induced by dopamine (DA) agonists are reversed by antipsychotics. Inhibition of the striatum-rich phosphodiesterase (PDE)10A may represent a novel...
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| Auteurs principaux: | , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2748940/ https://ncbi.nlm.nih.gov/pubmed/19066855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-008-1419-x |
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