Evaluating the antipsychotic profile of the preferential PDE10A inhibitor, papaverine

RATIONALE: Prepulse inhibition (PPI) is an operational measure of sensorimotor gating that is deficient in schizophrenia patients. In rats, PPI deficits induced by dopamine (DA) agonists are reversed by antipsychotics. Inhibition of the striatum-rich phosphodiesterase (PDE)10A may represent a novel...

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Bibliographic Details
Main Authors:	Weber, M., Breier, M., Ko, D., Thangaraj, N., Marzan, D. E., Swerdlow, N. R.
Format:	Artigo
Language:	Inglês
Published:	2008
Subjects:	Article
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2748940/ https://ncbi.nlm.nih.gov/pubmed/19066855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-008-1419-x
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Evaluating the antipsychotic profile of the preferential PDE10A inhibitor, papaverine

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