An Expressed Fgf4 Retrogene Is Associated with Breed-Defining Chondrodysplasia in Domestic Dogs

Retrotransposition of processed mRNAs is a frequent source of novel sequence acquired during the evolution of genomes. The vast majority of retroposed gene copies are inactive pseudogenes that rapidly acquire mutations that disrupt the reading frame, while precious few are conserved to become new ge...

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Autori principali: Parker, Heidi G., VonHoldt, Bridgett M., Quignon, Pascale, Margulies, Elliott H., Shao, Stephanie, Mosher, Dana S., Spady, Tyrone C., Elkahloun, Abdel, Cargill, Michele, Jones, Paul G., Maslen, Cheryl L., Acland, Gregory M., Sutter, Nathan B., Kuroki, Keiichi, Bustamante, Carlos D., Wayne, Robert K., Ostrander, Elaine A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748762/
https://ncbi.nlm.nih.gov/pubmed/19608863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1173275
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