Interleukin-13 Displaying Retargeted Oncolytic Measles Virus Strains Have Significant Activity Against Gliomas With Improved Specificity

The majority of glioblastoma multiforme (GBM) tumors (80%) overexpress interleukin-13 receptor α2 (IL-13Rα2), but there is no expression of IL-13Rα2 in normal brain. Vaccine strains of measles virus have significant antitumor activity against gliomas. We tested the hypothesis that measles virus entr...

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Bibliografski detalji
Glavni autori: Allen, Cory, Paraskevakou, Georgia, Iankov, Ianko, Giannini, Caterina, Schroeder, Mark, Sarkaria, Jann, Puri, Raj K, Russell, Stephen J, Galanis, Evanthia
Format: Artigo
Jezik:Inglês
Izdano: 2008
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748750/
https://ncbi.nlm.nih.gov/pubmed/18665158
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2008.152
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