Deafness in TRβ Mutants Is Caused by Malformation of the Tectorial Membrane

Thyroid hormone receptor β (TRβ) dysfunction leads to deafness in humans and mice. Deafness in TRβ(−/−) mutant mice has been attributed to TRβ-mediated control of voltage- and Ca(2+)-activated K(+) (BK) channel expression in inner hair cells (IHCs). However, normal hearing in young constitutive BKα(...

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Autors principals: Winter, Harald, Rüttiger, Lukas, Müller, Marcus, Kuhn, Stephanie, Brandt, Niels, Zimmermann, Ulrike, Hirt, Bernhard, Bress, Andreas, Sausbier, Matthias, Conscience, Aude, Flamant, Frederic, Tian, Yong, Zuo, Jian, Pfister, Markus, Ruth, Peter, Löwenheim, Hubert, Samarut, Jacques, Engel, Jutta, Knipper, Marlies
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2009
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748340/
https://ncbi.nlm.nih.gov/pubmed/19244534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.3557-08.2009
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