Mycobacterium tuberculosis Cell Wall Glycolipids Directly Inhibit CD4(+) T-Cell Activation by Interfering with Proximal T-Cell-Receptor Signaling

Immune evasion is required for Mycobacterium tuberculosis to survive in the face of robust adaptive CD4(+) T-cell responses. We have previously shown that M. tuberculosis can indirectly inhibit CD4(+) T cells by suppressing the major histocompatibility complex class II antigen-presenting cell functi...

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Detalhes bibliográficos
Main Authors: Mahon, Robert N., Rojas, Roxana E., Fulton, Scott A., Franko, Jennifer L., Harding, Clifford V., Boom, W. Henry
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747961/
https://ncbi.nlm.nih.gov/pubmed/19651854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00222-09
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