Identification of 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones as isoform-selective PKC-ζ inhibitors and potential therapeutics for psychostimulant abuse

From a screen of small molecule libraries to identify potential therapeutics for psychostimulant abuse, 3-hydroxy-2-(3-hydroxyphenyl)-4H-1-benzopyran-4-ones were shown to be isoform-selective PKC-ζ inhibitors.

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Detalhes bibliográficos
Main Authors: Yuan, Langtian, Seo, Jin-Soo, Kang, Nam Sook, Keinan, Shahar, Steele, Sarah E., Michelotti, Gregory A., Wetsel, William C., Beratan, David N., Gong, Young-Dae, Lee, Tong H., Hong, Jiyong
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747283/
https://ncbi.nlm.nih.gov/pubmed/19668856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b903036k
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