Timosaponin AIII Is Preferentially Cytotoxic to Tumor Cells through Inhibition of mTOR and Induction of ER Stress

The aqueous extract of Anemarrhena asphodeloides (BN108) induces apoptosis in various cancer cell lines but is significantly less cytotoxic in non-transformed cells. Chemical fractionation of BN108 showed that its cytotoxicity is associated with timosaponins, steroidal saponins of coprostane type. T...

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Bibliografische gegevens
Hoofdauteurs: King, Frank W., Fong, Sylvia, Griffin, Chandi, Shoemaker, Mark, Staub, Rick, Zhang, Yan-Ling, Cohen, Isaac, Shtivelman, Emma
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2009
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747272/
https://ncbi.nlm.nih.gov/pubmed/19789631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007283
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