Reduced arsenic clearance and increased toxicity in aquaglyceroporin-9-null mice

Expressed in liver, aquaglyceroporin-9 (AQP9) is permeated by glycerol, arsenite, and other small, neutral solutes. To evaluate a possible protective role, AQP9-null mice were evaluated for in vivo arsenic toxicity. After injection with NaAsO(2), AQP9-null mice suffer reduced survival rates (LD(50),...

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Main Authors: Carbrey, Jennifer M., Song, Linhua, Zhou, Yao, Yoshinaga, Masafumi, Rojek, Aleksandra, Wang, Yiding, Liu, Yangjian, Lujan, Heidi L., DiCarlo, Stephen E., Nielsen, Søren, Rosen, Barry P., Agre, Peter, Mukhopadhyay, Rita
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747225/
https://ncbi.nlm.nih.gov/pubmed/19805235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908108106
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