Lack of TNFα expression protects anaplastic lymphoma kinase-positive T-cell lymphoma (ALK+ TCL) cells from apoptosis

Here we report that T-cell lymphomas characterized by the expression of anaplastic lymphoma kinase (ALK+ TCL) fail to express the TNFα and frequently display DNA methylation of the TNFα gene promoter. While only a subset of the ALK+ TCL-derived cell lines showed a high degree of the promoter methyla...

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Autors principals: Zhang, Qian, Wang, Hong Y., Bhutani, Gauri, Liu, Xiaobin, Paessler, Michele, Tobias, John W., Baldwin, Donald, Swaminathan, Kunchithapadam, Milone, Michael C., Wasik, Mariusz A.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2009
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747206/
https://ncbi.nlm.nih.gov/pubmed/19717436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907070106
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