Double-strand DNA breaks recruit the centromeric histone CENP-A

The histone H3 variant CENP-A is required for epigenetic specification of centromere identity through a loading mechanism independent of DNA sequence. Using multiphoton absorption and DNA cleavage at unique sites by I-SceI endonuclease, we demonstrate that CENP-A is rapidly recruited to double-stran...

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Main Authors: Zeitlin, Samantha G., Baker, Norman M., Chapados, Brian R., Soutoglou, Evi, Wang, Jean Y. J., Berns, Michael W., Cleveland, Don W.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747192/
https://ncbi.nlm.nih.gov/pubmed/19717431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908233106
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