Switch from perforin-expressing to perforin-deficient CD8(+) T cells accounts for two distinct types of effector cytotoxic T lymphocytes in vivo

Although CD8(+) cytotoxic T lymphocytes (CTL) exhibit both Fas ligand (FasL) -based and perforin-based lytic activities, the accepted hallmark of a fully active CTL remains its perforin killing machinery. Yet the origin, rationale for possessing both a slow-acting (FasL) and a fast-acting (perforin)...

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Bibliographische Detailangaben
Hauptverfasser: Meiraz, Avihai, Garber, Orit Gal, Harari, Shaul, Hassin, David, Berke, Gideon
Format: Artigo
Sprache:Inglês
Veröffentlicht: Blackwell Science Inc 2009
Schlagworte:
Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747140/
https://ncbi.nlm.nih.gov/pubmed/19689737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2567.2009.03072.x
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