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Cardiomyocyte-specific loss of neurofibromin promotes cardiac hypertrophy and dysfunction

BACKGROUND: Neurofibromatosis type I (NF1) is a common autosomal dominant disorder with a broad array of clinical manifestations, including benign and malignant tumors, and characteristic cutaneous findings. NF1 patients also have an increased incidence of cardiovascular diseases, including obstruct...

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Detalhes bibliográficos
Main Authors: Xu, Junwang, Ismat, Fraz A., Wang, Tao, Lu, Min Min, Antonucci, Nicole, Epstein, Jonathan A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747036/
https://ncbi.nlm.nih.gov/pubmed/19574548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.109.201509
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