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A conserved ubiquitination pathway determines longevity in response to diet restriction
Dietary Restriction (DR) extends longevity in diverse species suggesting that there is a conserved mechanism for nutrient regulation and prosurvival responses1. We have discovered a role for the HECT E3 ubiquitin ligase WWP-1 as a positive regulator of lifespan in C. elegans in response to diet rest...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2009
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2746748/ https://ncbi.nlm.nih.gov/pubmed/19553937 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature08130 |
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