A novel method for imaging in vivo degradation of poly(L-glutamic acid), a biodegradable drug carrier

PURPOSE: To develop an L-PG-based imaging probe suitable for assessing the degradation of L-PG in vivo. METHODS: Conjugates of L-PG and a near-infrared fluorescence (NIRF) dye, NIR813, were characterized with regard to quenching efficiency and degradability by cathepsin B (CB) and other proteases. T...

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Hlavní autoři: Melancon, Marites P., Wang, Wei, Wang, Yuetang, Shao, Ruping, Ji, Xiaojun, Gelovani, Juri G., Li, Chun
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746742/
https://ncbi.nlm.nih.gov/pubmed/17377742
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-007-9253-0
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