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Duplication Hotspots, Rare Genomic Disorders and Common Disease
The human genome is enriched in interspersed segmental duplications that sensitize approximately 10% of our genome to recurrent microdeletions and microduplications as a result of unequal crossing over. We review the recent discovery of recurrent rearrangements within these genomic hotspots and thei...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2746670/ https://ncbi.nlm.nih.gov/pubmed/19477115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gde.2009.04.003 |
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