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DNA-Based MRI Probes for Specific Detection of Chronic Exposure to Amphetamine in Living Brains

We designed phosphorothioate-modified DNA probes linked to superparamagnetic iron oxide nanoparticles (SPION) for in vivo magnetic resonance imaging (MRI) of fosB and ΔfosB mRNA after amphetamine (AMPH) exposure in mice. Specificity of both the fosB and ΔfosB probes was verified by in vitro reverse...

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Autors principals: Liu, Christina H., Ren, Jia Q., Yang, Jinsheng, Liu, Charng-ming, Mandeville, Joseph B., Rosen, Bruce R., Bhide, Pradeep G., Yanagawa, Yuchio, Liu, Philip K.
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746375/
https://ncbi.nlm.nih.gov/pubmed/19710318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2167-09.2009
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