Susceptibility of Pancreatic Beta Cells to Fatty Acids Is Regulated by LXR/PPARα-Dependent Stearoyl-Coenzyme A Desaturase

Chronically elevated levels of fatty acids-FA can cause beta cell death in vitro. Beta cells vary in their individual susceptibility to FA-toxicity. Rat beta cells were previously shown to better resist FA-toxicity in conditions that increased triglyceride formation or mitochondrial and peroxisomal...

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Autori principali: Hellemans, Karine H., Hannaert, Jean-Claude, Denys, Bart, Steffensen, Knut R., Raemdonck, Cindy, Martens, Geert A., Van Veldhoven, Paul P., Gustafsson, Jan-Åke, Pipeleers, Daniel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2009
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746288/
https://ncbi.nlm.nih.gov/pubmed/19787047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007266
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