Structural and Kinetic Analyses of Macrophage Migration Inhibitory Factor (MIF) Active Site Interactions

Macrophage migration inhibitory factor (MIF) is a secreted protein expressed in numerous cell types that counters the anti-inflammatory effects of glucocorticoids and has been implicated in sepsis, cancer and certain auto-immune diseases. Interestingly, the structure of MIF contains a catalytic site...

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Bibliografiske detaljer
Main Authors: Crichlow, Gregg V., Lubetsky, Jodi B., Leng, Lin, Bucala, Richard, Lolis, Elias J.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746060/
https://ncbi.nlm.nih.gov/pubmed/19090677
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi8014423
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