Downregulation of heat shock protein 70 protects rheumatoid arthritis fibroblast-like synoviocytes from nitric oxide-induced apoptosis

INTRODUCTION: Heat shock protein 70 (Hsp70) is a well-known anti-apoptotic protein that blocks multiple steps in the stress-induced apoptotic pathway. Enhanced Hsp70 expression has previously been demonstrated in rheumatoid arthritis (RA) fibroblast-like synoviocytes (FLSs). The authors investigated...

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Hauptverfasser: Kang, Eun Ha, Kim, Dong Jo, Lee, Eun Young, Lee, Yun Jong, Lee, Eun Bong, Song, Yeong Wook
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2009
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745814/
https://ncbi.nlm.nih.gov/pubmed/19709444
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar2797
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