Using Acetaminophen's Toxicity Mechanism to Enhance Cisplatin Efficacy in Hepatocarcinoma and Hepatoblastoma Cell Lines

BACKGROUND/AIMS: Acetaminophen overdose causes hepatotoxicity mediated by toxic metabolites generated through the cytochrome P450 enzyme. The objective of this study was to investigate whether acetaminophen (AAP) can enhance cisplatin (CDDP) cytotoxicity against human hepatocarcinoma and hepatoblast...

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Main Authors: Neuwelt, Alexander J, Wu, Y Jeffrey, Knap, Narcyz, Losin, Marcin, Neuwelt, Edward A, Pagel, Michael A, Warmann, Steven, Fuchs, Joerg, Czauderna, Piotr, Wozniak, Michal
Format: Artigo
Language:Inglês
Published: Neoplasia Press Inc. 2009
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745666/
https://ncbi.nlm.nih.gov/pubmed/19794959
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