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Rac1 activation inhibits E-cadherin-mediated adherens junctions via binding to IQGAP1 in pancreatic carcinoma cells

BACKGROUND: Monomeric GTPases of the Rho family control a variety of cellular functions including actin cytoskeleton organisation, cell migration and cell adhesion. Defects in these regulatory processes are involved in tumour progression and metastasis. The development of metastatic carcinoma is acc...

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Detalhes bibliográficos
Main Authors: Hage, Beatrix, Meinel, Katrin, Baum, Iris, Giehl, Klaudia, Menke, Andre
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745413/
https://ncbi.nlm.nih.gov/pubmed/19737400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1478-811X-7-23
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