Safety and Immunogenicity of the Merck Adenovirus Serotype 5 (MRKAd5) and MRKAd6 Human Immunodeficiency Virus Type 1 Trigene Vaccines Alone and in Combination in Healthy Adults

Preexisting immunity to adenovirus serotype 5 (Ad5) diminishes immune responses to vaccines using Ad5 as a vector. Alternate Ad serotypes as vaccine vectors might overcome Ad5-specific neutralizing antibodies and enhance immune responses in populations with a high prevalence of Ad5 immunity. To test...

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Bibliographic Details
Main Authors: Harro, Clayton, Sun, Xiao, Stek, Jon E., Leavitt, Randi Y., Mehrotra, Devan V., Wang, Fubao, Bett, Andrew J., Casimiro, Danilo R., Shiver, John W., DiNubile, Mark J., Quirk, Erin
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Vaccine Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745015/
https://ncbi.nlm.nih.gov/pubmed/19605598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00144-09
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