Structure—Activity Study of New Inhibitors of Human Betaine-Homocysteine S-Methyltransferase

Betaine-homocysteine S-methyltransferase (BHMT) catalyzes the transfer of a methyl group from betaine to l-homocysteine, yielding dimethylglycine and l-methionine. In this study, we prepared a new series of BHMT inhibitors. The inhibitors were designed to mimic the hypothetical transition state of B...

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Bibliografiske detaljer
Main Authors: Vaněk, Václav, Buděšínský, Miloš, Kabeleová, Petra, Šanda, Miloslav, Kožíšek, Milan, Hančlová, Ivona, Mládková, Jana, Brynda, Jiří, Rosenberg, Ivan, Koutmos, Markos, Garrow, Timothy A., Jiráček, Jiří
Format: Artigo
Sprog:Inglês
Udgivet: 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2744866/
https://ncbi.nlm.nih.gov/pubmed/19534555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm8015798
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