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Oxidative DNA Adducts Following Cu(2+)-Mediated Activation of Dihydroxy PCBs: Role of Reactive Oxygen Species

Polychlorinated biphenyls (PCBs) are toxic industrial chemicals, complete carcinogens and efficacious tumor promoters. However, the mechanism(s) of PCB-mediated carcinogenicity remains largely undefined. One likely pathway by which these agents may play a role in carcinogenesis is the generation of...

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Detalhes bibliográficos
Main Authors: Spencer, Wendy A., Lehmler, Hans-Joachim, Robertson, Larry W., Gupta, Ramesh C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2744390/
https://ncbi.nlm.nih.gov/pubmed/19233261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2009.02.005
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