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Core Structure of the yeast Spt4-Spt5 Complex: A Conserved Module for Regulation of Transcription Elongation

Spt4-Spt5 complex is an essential RNA Polymerase II elongation factor found in all eukaryotes and important for gene regulation. We report here the crystal structure of Saccharomyces cerevisiae Spt4 bound to the NGN domain of Spt5. This structure reveals that Spt4-Spt5 binding is governed by an acid...

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Bibliografiske detaljer
Main Authors: Guo, Min, Xu, Fei, Yamada, Jena, Egelhofer, Thea, Gao, Yongxiang, Hartzog, Grant A., Teng, Maikun, Niu, Liwen
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743916/
https://ncbi.nlm.nih.gov/pubmed/19000817
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2008.08.013
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