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Computational Selection of Inhibitors of A-beta Aggregation and Neuronal Toxicity
Alzheimer’s Disease (AD) is characterized by the cerebral accumulation of misfolded and aggregated amyloid-β protein (Aβ). Disease symptoms can be alleviated, in vitro and in vivo, by “β-sheet breaker” pentapeptides that reduce plaque volume. However the peptide nature of these compounds, made them...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2743868/ https://ncbi.nlm.nih.gov/pubmed/19540126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2009.05.047 |
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