The cyclin-dependent kinase inhibitor 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole induces nongenotoxic, DNA replication-independent apoptosis of normal and leukemic cells, regardless of their p53 status

BACKGROUND: Current chemotherapy of human cancers focuses on the DNA damage pathway to induce a p53-mediated cellular response leading to either G1 arrest or apoptosis. However, genotoxic treatments may induce mutations and translocations that result in secondary malignancies or recurrent disease. I...

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Detalhes bibliográficos
Main Authors: Turinetto, Valentina, Porcedda, Paola, Orlando, Luca, De Marchi, Mario, Amoroso, Antonio, Giachino, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743708/
https://ncbi.nlm.nih.gov/pubmed/19674456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-9-281
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