Molecular markers of response and toxicity to FOLFOX chemotherapy in metastatic colorectal cancer

BACKGROUND: To investigate three genetic alterations (TP53 mutation, Kras mutation and microsatellite instability (MSI)) and three polymorphisms (methylene tetrahydrofolate reductase (MTHFR) C677T, excision repair cross complementing group 1 (ERCC1)-118 and X-ray repair cross complementing group 1 (...

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Detalhes bibliográficos
Main Authors: Chua, W, Goldstein, D, Lee, C K, Dhillon, H, Michael, M, Mitchell, P, Clarke, S J, Iacopetta, B
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Molecular Diagnostics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2743363/
https://ncbi.nlm.nih.gov/pubmed/19672255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605239
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