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Interferon-λ Is Functionally an Interferon but Structurally Related to the Interleukin-10 Family
Interferon-λ (IFN-λ) is an antiviral cytokine that signals through a distinct receptor complex, composed of the IFN-λR1 and interleukin-10R2 (IL-10R2) receptor chains. We have determined the crystal structure of human IFN-λ3 and characterized the interaction with its receptor complex through structu...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Society for Biochemistry and Molecular Biology
2009
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2742852/ https://ncbi.nlm.nih.gov/pubmed/19457860 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.002923 |
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