The Effect of LRP5 Polymorphisms on Bone Mineral Density Is Apparent in Childhood

Bone mass acquired during childhood is the primary determinant of adult bone mineral density (BMD) and osteoporosis risk. Bone accrual is subject to genetic influences. Activating and inactivating LRP5 gene mutations elicit extreme bone phenotypes, while more common LRP5 polymorphisms are associated...

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Autori principali: Koay, M. Audrey, Tobias, Jonathan H., Leary, Sam D., Steer, Colin D., Vilariño-Güell, Carles, Brown, Matthew A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2007
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742716/
https://ncbi.nlm.nih.gov/pubmed/17505772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00223-007-9024-2
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