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Direct observation of barrier-limited folding of BBL by single-molecule fluorescence resonance energy transfer

One controversial area in protein folding mechanisms is whether some small, ultra-fast-folding proteins exist in distinct native and denatured state ensembles, separated by an energy barrier, or if there is a continuum of states between native and denatured. In theory, the simplest way of distinguis...

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Detalhes bibliográficos
Main Authors: Huang, Fang, Ying, Liming, Fersht, Alan R.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742407/
https://ncbi.nlm.nih.gov/pubmed/19805287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0909126106
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