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Inhibition of protein kinase C signaling protects prefrontal cortex dendritic spines and cognition from the effects of chronic stress

The prefrontal cortex r regulates behavior, cognition, and emotion by using working memory. Prefrontal functions are impaired by stress exposure. Acute, stress-induced deficits arise from excessive protein kinase C (PKC) signaling, which diminishes prefrontal neuronal firing. Chronic stress addition...

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Main Authors: Hains, Avis Brennan, Vu, Mai Anh T., Maciejewski, Paul K., van Dyck, Christopher H., Gottron, Melissa, Arnsten, Amy F. T.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742406/
https://ncbi.nlm.nih.gov/pubmed/19805148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0908563106
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