Blockade of IP(3)-mediated SK channel signaling in the rat medial prefrontal cortex improves spatial working memory

Planning and directing thought and behavior require the working memory (WM) functions of prefrontal cortex. WM is compromised by stress, which activates phosphatidylinositol (PI)-mediated IP(3)-PKC intracellular signaling. PKC overactivation impairs WM operations and in vitro studies indicate that I...

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Detaylı Bibliyografya
Asıl Yazarlar: Brennan, Avis R., Dolinsky, Beth, Vu, Mai-Anh T., Stanley, Marion, Yeckel, Mark F., Arnsten, Amy F.T.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Cold Spring Harbor Laboratory Press 2008
Konular:
Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275660/
https://ncbi.nlm.nih.gov/pubmed/18285467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/lm.767408
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