Blockade of IP(3)-mediated SK channel signaling in the rat medial prefrontal cortex improves spatial working memory

Planning and directing thought and behavior require the working memory (WM) functions of prefrontal cortex. WM is compromised by stress, which activates phosphatidylinositol (PI)-mediated IP(3)-PKC intracellular signaling. PKC overactivation impairs WM operations and in vitro studies indicate that I...

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Detalhes bibliográficos
Main Authors: Brennan, Avis R., Dolinsky, Beth, Vu, Mai-Anh T., Stanley, Marion, Yeckel, Mark F., Arnsten, Amy F.T.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2008
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2275660/
https://ncbi.nlm.nih.gov/pubmed/18285467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/lm.767408
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